Intracellular trafficking of CFTR (Rattus norvegicus)
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Description
This pathway describes the mechanism of endo- and exocytosis of CFTR channel, based on the article: “New insights into cystic fibrosis: molecular switches that regulate CFTR” by Guggino et al. 2006. On the left side (in red) the endocytic mechanism is shown. Respectively in green on the right sight the exocytic mechanism. We integrated the functions of PDZ proteins, SNAREs and Rho GTPases.
Bibliography
| View all 6 references |
- ''; '', - PubMed
- Gentzsch M, Chang XB, Cui L, Wu Y, Ozols VV, Choudhury A, Pagano RE, Riordan JR; ''Endocytic trafficking routes of wild type and DeltaF508 cystic fibrosis transmembrane conductance regulator.; ''Mol Biol Cell, 2004 - PubMed
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Pathway Info
DataNodes
| View all 15 DataNodes |
| Name | Type | Backpage Header | Database reference |
|---|---|---|---|
| CFTR | Protein | AAA73561.1 (Other) | |
| Cftr | Protein | ENSRNOG00000008284 (Ensembl Rat) | |
| Tc10 | GeneProduct | 85428 (Entrez Gene) | |
| NHERF1 | Protein | Q9JJ19 (Uniprot/TrEMBL) | |
| CAL | GeneProduct | 362650 |
