G1Unattached kinetochoresUbiquitin mediated proteolysisCondensinMBFhighUBA (E1)SNutrientsAPC/CyclosomeARSSpindle checkpointSTARTORC (OrigninMaintenance) ComplexDNAMCM (Mini-ChromosomeRecognition Complex)lowDNA damage checkpoints26SProteasomeeSCBS-phaseproteinsDNADNAeMSCF (E3)pre-RCG2Pheromone(mating signal)MCBSBFUBC (E2)low2Far1Mad1MCMApc8Cdc46Dbf20Cdc53Clb3Mik1Mcm2Rad9Rad9Apc2Cdc6Fus3Cdc28Orc1Cdc34Bub2Apc11Cdc47Rad53Pho85Tem1Sic1Swi5Scc2Cdc5Apc9Byr4Cdh1Mec1Rad24Orc3Mbp1Cdc27Mps1Mih1Cdc23Cdc20Swe1Orc6Ycg1Cdc28Cdc26Cks1Hsl1Second messanger signaling pathwaySic1Mcm6Pho81Skp1CondensinCln1Apc1Mob1Rad17Pho4Swi4Dam1Brn1Cdc5Pds1Rad26Rad1Met30Mcm3Mec3Orc2Cdc7Smc2Pho85Cdc54Rad25Pcl1Cdc34Bub1Skp1Esp1Hsl7Doc1Chk1PhosphateApc4Cdc4Mad2Pds1Lte1Esc5Grr1Cln3Cdc34Cdc45ORCSco1MAPK signalingpathwayCdc15Clb5Swi6Tup1Dbf4Skp1Gin4Dbf2Apc5Loc7Bub3Clb1Cdc28Pho5Mad3Cdc28Cdc16APCUba1Rad24Pho2Ssn6Crt1Cdc53DNA biosynthesisDcd1Cdc53Orc5Swi6Rad9Cdc28Cak1Smc4Hus1Pho80Orc4Cdc14Cyclic AMPPPPPPPPPP1PPPPPPPPPPPPAPC