42163246, 7175419, 3115, 42234165352, 2620, 23, 2719, 22, 3024217, 3114, 2917, 3120, 23, 2740423616311813637411316356, 426, 1141351615, 4217421310, 393555374, 3025, 3836PI 3-Kinase isoformsErk SignalTransduction PathwaymTORC1Glucose UptakeInhibitionp70 S6 KinasesPancreatic Beta-cell proliferationHepatocyteLegendActivationAmpk isoformsInsulin Receptor SubstratesT3RAF1PI(3,4,5)P3INSRglycogenLXRPIK3CDTSC1Cell GrowthDifferentiationRASPIK3R1GCKmTORPTPSREBP2PIK3CAIRS2PP2AGlucosePIK3CGPI(4,5)P2IRS4PIK3R4Protein synthesis and Translation RegulationG-6-PSREBP1a-camino acidsPPARalphaAutophagy SignalingGLUT1 AMPKPathwayPIK3C2GSEST3SOS1PIK3CBGlycolysis-GluconeogenesisLPLPIK3R2ChrebpmTORTSC2InsulinX-5-PFBPRictorRHEBCIP42PIK3R3Triacylglyceride SynthesisG6PCInsulin Signaling Pathway GLUT4SOS2SIN1PIK3C3GSGRB2SREBP Pathwaymlst8RPS6KB1RPS6KB2IRS1RaptorF-2,6-P2PEPCKPIK3C2AGlycogenesisExo704034DIO2RXRATHRATHRBSLC16A2SLCO1C1T3T4RXRAANGPTL8T3 and T4 intracelullar uptakeSHC2SHC3SHC1GSK3AGSK3BPDKPKB/Akt isoformsAKT1AKT2pT308pT308EIF4EEIF4EBP1mlst8mTORSIN1Rictorpmlst8mTORC2FOXO1AFOXO3AmTORC2INSRCAP1CBLFLOT1FLOT2CRKRAPGEF1RHOQTransport of GLUT4 Transporters toPlasma MembraneRictorRXRA8, 28ABCG824FASN12ABCG524CYP3A4CYP7A11212CYP2B612LXR target genesDrug and steroidmetabolism33Multi-drugresistancelipogenesisSCDTranscriptionfactorsMEK/MAP Kinasesp90 Rsk KinasesMAP2K1MAP3K7MAPK14MAPK1MAP2K2RPS6KA5MAP3K2MAP3K6MAPK8MAP4K1MAP3K11MAP4K3MAPK10RPS6KA6MAP2K7MAP3K4MAP3K1MAP3K12MAPK4RPS6KA4MAPK11MAP4K5MAPK6MAP4K4MAPK3MAP3K14MAPK12MAP2K5MAP2K4MAPK13RPS6KA1RPS6KA2MAP3K5RPS6KA3MAPK9MAPK7MAP3K3MAP3K9MAP3K8MAP2K6MAP3K13MAP4K2MAP2K3MAP3K10MINK1PI(3,4,5)P3PKB/Akt isoformsAKT1pT308AKT2pS473pS473pT308CBLCCBLBFOXO1AFOXO3AInsulinINSRLXR target genes33CatalysisInsulin Signaling Pathway Undefined MechanismT4Activation from within the PathwayAMPKy3AMPKa1AMPKy2AMPKy1AMPKb2AMPKb1AMPKa2Ampk isoforms3825, 38