7CYP3A4CYP2C191endogenous cannabinoidsCBD catabolismNeuronal cell of CNS(hyppocampus, cerebellum or basal ganglia)inactiveInhibition of Glutamate or GABA release in synaptic cleftLeukocytes, spleen, thymus, bone marrowand other tissues associated with immune functionsHepG2 cellsADCY1CNR1CYP2C911-OH-THCMAPK PKAPhosphatidylethanolamineDAGLBcAMP AHRNAPEPLD4ADCY75NAPEDAGLA4Arachidonic acidTHC1''-hydroxycannabidiol12-arachidonoylglycerolprotein tyrosine kinasesFAAH4GlutamateADORA2A6CNR2CalciumGABA CBDATPAEAAnti-inflammatory pathwaysCOOH-THC3CYP1A12PKAATPcAMP CBD2''-hydroxycannabidiol 13''-hydroxycannabidiol 14''-hydroxycannabidiol 15''-hydroxycannabidiol 16a-hydroxycannabidiol 16b-hydroxycannabidiol 17-hydroxycannabidiol 1endogeneous cannabinoid synthesis