1Notch Intracellular domain- Abnormal angiogenesis- Stem cell maintenance- High levels of Ki67HIF1AVEGFAHIF1ANMIR31HEY1HES1MIR148AHIF1AVEGFBVEGFCHIF1A- More normalized vessels- Reduced stemness- Low levels of Ki67Fast tumor growth and short lifespanSmaller tumor size and lifespan extendedNICD