18DNA condensingtrimethyl lysine 27AstrocytesCis-Regulatory Elementsregulation of long noncoding RNAMECP2 - HDAC complex Trans-regulator Elements stimulate/inhibit by Polyadenylation of Mecp2 Promotor elementsregulation by miRNA (mostly posttranscriptional repression)alternative splicing transcriptional and translational regulation of MECP2MECP2 influences protein synthesis via AKT/mTOR pathwaymacropinocytosis cell proliferationOligodendrocytesList of genes and metabolites which are up or downregulated in Rett syndrome upregulated by MECP2Microgliaeffects on specific cellsHistone deacetylationregulation of miRNAneuronal activity leads to increase of Ca2+ Activation of transcription (stop of inhibition, res. from phosphorylated MECP2)cofactorsDNA binding1FGF4MEF2CE2F1GAMTMTORIGF2hsa-miR-199a-5phsa-miR-409-3pMPP1hsa-miR-483-5phsa-miR-222-3pBRN2hsa-miR-197-3p hsa-miR-221-5pGlutamateMelatoninBCL6hsa-miR-30a-3p DLX5NorepinephrinePI3K/MAPK CSRP1HNRNPH1TET1GRIN1Ak081227GAD1MECP2HNRNPFRPS6SGK1HP1BRN3FKBP5MBPCNPTAP1GRID1GABAC/EBPhsa-miR-146a-5p AKT1hsa-miR-137MYT1NREPhsa-miR-296-5phsa-miR-122-5pHB1hsa-miR-92a-3p NCOR1TET3hsa-miR-146b-3p NF1DLX5hsa-miR-382-3pDLX6FGF5EZH2hsa-miR-29b-1-5p hsa-miR-329-5pTAF1CDONhsa-miR-132-5pMYT1hsa-miR-152-3p DopamineAk087060SerotoninSMC3OPRK1MAGSerotoninAMPAH3NorepinephrineCTCFARHGEF26hsa-miR-130b-3pSP1PRPF3FGF2hsa-miR-193a-5p RESThsa-miR-342-3pUBE3ACytosine methylation NMDASSTSIN3Ahsa-miR-199b-5p hsa-miR-221-3pMyoinositolRBFOX1SP3hsa-miR-187-5p hsa-miR-184 FGF3hsa-miR-130aBDNFHDAC1APOC2CAMK2Ahsa-miR-199a-3pDopamineTET2FUT8GABRR2GPRIN1186361853181822182428232513221823191522125212218187171818231822181822181485262221543112221222022222718532218262118272232668, 9108, 128, 161718YB112, 15MECP2MECP2MECP2SP1Glutamate5, 264GABACREB1PPRPS6PBDNF18GAMT3down regulated by MECP2Glutamate4upregulated by MECP2down regulated by MECP2GABAMECP2