1Recipient cellMultivesicular bodiesRTKExosomeHost cellPackaging of proteinsEGFRvIIIRTK ligandTGFBR3CTNNB1HGFMTORERBB2FrizzledTGFAAKT1KRASDKK4APCTGFB3EGFRSMAD3MFGE8PI3KNRASTSPAN8CD133SMAD4HGFRTGFB1WNTTGFBR1RAF1WNT3AAXIN1WNT5ATGFB2MAPKSMAD2TGFBR2TGFB1HRASMutant KRASPPExosome mediatedsignal transductionAKT1