2protein-protein interactionProliferationLEGENDLCKZAP70PIP2LAT / SLP-76 scaffold complexPIP3PLCG1ITKAKT1PKC-aSHP1P13KCa2+Bcl-xLErkNFKB1AP-1 NFAT1Ras-GAPRas-GTPDAGIP3CalmodulinRasGRPIL2CalcineurinIkBaIKK complexinhibitionactivation / recruitmentphosphorylationdephosphorylationnecessary precursorPTENPDK1SurvivalRas-GDPPIP2signaling moleculetranscription factortarget geneMHC peptideB7-1/ B7-2B7-1/ B7-2PD-L1ligandNFAT1PCSNK1A1GSK3AGSK3BDYRK1ADYRK2NRON1FYNTCRATCRBCD8ACD8BCD28CTLA4PDCD1