Sensory motor nerveVasocontrictionPGI2eNOSCOX2cAMPY1L-ArginineArachidonic acidCa2+ channelsGCK+CitrullineK+ channelIP1EDHFCa2+ channelPKAcGMPNOGTPSERCAK+a adrenergic receptorNPYCGRPCRLRATPRAMP1ACEndothelin 1ECEIP3CapPKCGaQMLCBig ET1MEKEDNRAMLCKDAGERK1/2EDNRBFurin-like proteaseRAFPLCbIP3RPre-pro ET1CADCa2+CaMPIP2Pre-pro ET1Endothelin 1GbQGgQCa2+PMCACa2+EDNRBGaQGbQGgQPLCbPIP2IP3DAGCa2+Ca2+Ca2+ channelIP3RNOPGI2PKCCa2+K+GaSGbSGgSGaQGbQGgQb adrenergic receptorGaSGbSGgSSympathic nerveEndothelial cellSmooth muscle cellK+CGRPCGRPGaSGbSGgSK+K+NPYNPYGaIGbIGgINONOCa2+Cellular growth and survival