1-3, 6-9, 12...171927541141110294, 22, 2625, 29p-Aggr. amyloidCalcium overloadCell deathOligomeric intracellular ABMicrogliaMitochondiral dysfunctionalpha-SecretaseAmyloid Beta (AB)C83sAPP-alphaAICDMitochondrial dysfunctionATP depletionNeuronal InjuryEndoplasmic reticulum (ER)NeuronLower energy production?ApoptosisInduction of ApoptosisIronOxidative PhosphorylationCalciumNOCalcium Signaling PathwayProtein oxidationModulation of gene expressionAPPBP1APPCopperIP3Hydrogen peroxideMIR101APBB1GAPDHADAM10BACE1PSENENPSEN1NCSTNAPH1AIDEMMELPLAPOELRP1FASTNFRSF1AFADDCASP8Cx ICx IICx IIICx IVCx VAPP processingbeta-Secretasegamma-SecretaseHSD17B10Fall in mitochondrialsAPP-betaC99membrane potentialIncreased ROSDegredationInactivationBIDCYCSCALM1CHPBADCALM2CALM3CALML3CALML5PPP3CAPPP3CBPPP3CCPPP3R1PPP3R2CHP2ADAM17PSEN2APAF1CASP9CASP3AB AggregationOligomeric ABalpha-synucleinSNCASenileplaqueNACGPCRGRIN1CACNA1CGRIN2AGRIN2BGRIN2CGRIN2DCACNA1DCACNA1FCACNA1SGNAQPLCB1PLCB2PLCB3PLCB4TNFIL1BMAPK1MAPK3CASP12ApoptosisRYR3PSENENATP2A2ATP2A1ATP2A3EIF2AK3ERN1ATF6ITPR1ITPR2ITPR3CalciumCalciumER stressCAPN1CAPN2TP53CDK5R1NOS1CDK5TAUPGSK3BPCASP3CASP7Paired helical filaments (PHFs)Neurofibrillarytangles (NFTs)ABApoptosisDNA damageInflammationLipid peroxidationONOO-15Based on Table 1 from Burgos et al, PLoS ONE 2014 May.miRNA differentially expressed in AD(measured in cerebrospinal fluid)MIR199BMIR381MIR181B1MIR124-2MIR181DMIR124-1MIR760MIR184MIR136MIR181A1MIR598MIR181A2MIR127MIR34BMIR101-1MIR95MIR488MIR138-2MIR769MIR218-1MIR181B2MIR138-1MIR218-2MIR495MIR708MIR874MIR873MIR129-1MIR129-2MIR139MIR3200MIR431MIR9-1MIR9-2MIR9-3MIR326MIR377MIR433MIR323AMIR134MIR329-1MIR329-2MIR10AMIR33BMIR410MIR708miRNA differentially expressed in AD(measured in blood serum)MIR219-2MIR22MIR125B1MIR1307MIR34CMIR34BMIR887MIR182MIR135A1MIR135A2MIR184MIR127MIR30C2MIR873MIR125AMIR671MIR21MIR1285-2MIR375MIR3176MIR124-3MIR29AMIR29B1MIR29CMIR132MIR34CMIR375MIR124-3MIR9-1MIR138-2MIR138-2MIR132MIR21MIR21MIR21MIR21MIR21MIR1285-2