6Target GenesTarget GenesUpregulation proteasesCel replicationCapillary tubule formationProliferation and differentiationof ECs, SMCs and fibroblastsStabilization of newly formedvesselsCell growth and divisionAttraction of pericytes and SMCsNucleusHRESurvivalProliferationMigrationHypoxia CytoplasmExtracellularVessel StabilizationEPC mobilizationBasement membranedegradationVascularPermeabilityDNAVascular budding throughEPC recruitionFGF2SRCFGFR2HIF1AMMP9MMP2SMAD1FLT1PI3KsTIE2PLCG1VEGFAHIF1AVEGFAARNTCBPAKT1Ang 1Ang 1TIMP3FAKMMP9MAPK1PDGFBFGF2TIE2p38 MAPKMMP2PDGFRAVEGFR2TIMP2NOSPDGFB12, 142, 4, 107, 112, 4, 103, 9, 11, 1312, 147, 112, 4, 103, 9, 11, 133, 9, 11, 134, 62, 4, 107, 117, 11651, 5, 111, 5, 112, 4, 1012, 141, 5, 112, 4, 10