2203, 20831, 67, 137, 25717026, 69, 93, 101, 142...1311372, 20, 190, 223293, 2498, 211, 238501068138, 24635, 17620, 56, 192, 2173553226StimulationSelenium statusCatalysisStatusBiomarker forNegative EffectOverarching processProtein tyrosine nitrationBindingSelenoproteinsCofactorsMicronutrientsInflammation and immune responseInhibitionCleavageLEGENDOxidative stressReactionFrom intracellular part to the plasmais composed ofLipoprotein melabolismMetabolitesGlycogenesisProcess or metabolism involved in Se PathwayProstaglandins metabolismTryptophan metabolismTranscription factorOther proteinsCofactor conversionLipid peroxidationMetabolic stressCa++ metabolismNecessary stimulationConversionEnzymesLeukotriene metabolismIntracellularGlutathione metabolismER protein foldingNAD+ metabolismFolate metabolismDNA oxidationPlasmaPGH2a-TocopherolLipoxin A4PGH3RELADGLAPGE1PGI2F2-IsoprostaneCOX1F2-Isoprostane8-Isoprostaglandin F2aPGF2aEPAPGF2aa-Tocopherol8-Isoprostaglandin F2aCOX2Thromboxane B2MDALinoleic acidMDALipoxin A4PGD2Arachidonic acidPGE1DPALipoxin B4EPAALAPGI2DHALipoxin B4PGG2PGE2DPANFkB2DHAALALinoleic acidPGD2PGE3Thromboxane A2NFkB1Arachidonic acidPGE2Thromboxane B2636316983, 183, 219, 233, 245...24922286111, 15986, 20922271757571, 7563111, 24062, 7222263391118662, 86, 121, 165, 169...7119, 11111111183, 219, 233, 245, 266180, 25271, 75121, 180, 222, 252, 26562, 728662, 72249180, 25222239, 102, 11111112186, 121, 169, 25326511139Kynurenine176MTR113, 131TRXR1CBS113, 185IodineIodine4646KMO176R-Triiodothyronine (rT3)5-HETER-Triiodothyronine (rT3)5-HPETE15-HETEThyroxine (T4)Triiodothyronine (T3)Triiodothyronine (T3)15-HETE5-HETE5,6-EpoxytetraeneThyroxine (T4)46, 16446, 1646363, 26552, 69, 26598, 16426552, 69, 26598, 16498, 16452, 69, 26546, 164NADP+MPOCatalaseMPO14, 25, 223, 2412232, 66Uric acid91, 203CysteinePAI-1ThrombinGGT1ThrombintPAPLGtPAPLGFactor VIIFactor VIIPAI-110310360, 163103103122, 163129122, 16310310360, 163GPX 4TRXR2Xantine oxidase91, 135PRDX5H2O2ALOX5ALOX15B151, 26563, 165, 219, 234, 259CopperUric acid91, 203Vitamin B1232, 1335,10-Methylene-THFSelR190, 224Tryptophan35, 1765-methyl-THFSOD3PRDX1RFK214H2OGPX 3NiacinamideCTH113PNPO152Heme2, 66, 81, 102, 185NADPHLipoic acid67ManganeseFAD221Methionine sulfoxide190Dehydroascorbic acid218, 257Leukotriene A4239, 242NADPHFAD221THFHydroxykynurenine176Folic acid131NADP+NADPHSeleniumSelenium8888SelKSep1520, 90, 192256GPX 6GSH244Nicotinamidase35Calcium239Methionine190ManganeseNADPHFolic acid131FMN221SelenideSelenocysteineSelenophosphate31, 16431, 16431, 164CysteineLeukotriene C4Leukotriene C4129, 239GPX 326Dehydroascorbic acid257GPX 2SelP160Trx-S267, 137, 257Ascorbic acid218Lipoic acid67PRDX4GPX 1NADP+HomocysteineROSRNS2, 8, 16, 28, 40...2, 50NADPHVitamin B1232, 133MTHFR131Homocysteine60SelODIO1SelVSelISelNSelTDIO3DIO2SelSSelPSelMSPS2SelH164, 2157070, 211, 23824, 49, 160, 17256, 107, 1457046, 164, 2626, 40, 217708, 7046, 16446, 16453, 125SOD1Pyridoxal 5'-phosphate176SerineIron239HypoxanthinePRDX3GSR130oxLDLSAA1SAA2oxLDLVLDL-TAGLDLRHDLSAA3HDL/APOA1LDLCholesterolABCA1APOBHDLTAGTAGACTHDL/SAAVLDL-TAGVLDLSAA4FMNVLDL/APOBHDL-CSRB1APOA1CholesterolAPOA1-NO2TyrVLDLLDLAPOA1APOBACTHDL-C45, 64, 24624624610824647, 110, 17864, 24664, 246178108246108, 14864, 24622110810824645, 24624645108108, 14814, 38, 93, 101, 18310824614, 38, 93, 101, 18319124610864, 24614, 38, 93, 10124647, 110, 17814, 38, 93, 101O2249Pyridoxal 5'-phosphate176FAD8-OHdG8-OHdG226226221PRDX2ADPLeukotriene D4Leukotriene D4129ChlorineChlorineCopperCystathionineFAD221SOD2Dihydrolipoate28, 67SerineNADP+ATPZincNADP+GSSGNADPHZincNiacinLeukotriene B4Leukotriene B4242239, 242Quinolinic Acid35, 176PMPO3NONOHOClNO2HNO225, 24125, 241NADP+GSH53, 242, 244D-dimerFibrinogenHBA1CCL2IL6FibrinogenIL1BINSsICAM-1IL1BIL10sICAM-1ALBALBHbA1cIFNgTNFaCCL2D-dimerTNFaFLAPIFNgINSHbA1cCRPFibrinINSRHBBIL10IL6Fibrin1867, 49, 2622465, 106, 206, 23565, 106, 148, 206, 23565, 235103, 1557, 144, 2131077, 144, 21393, 144, 183, 204186, 204, 26216, 241571577, 16, 107, 175103, 122262264103, 1222415716, 2423426426249, 107, 175103, 155186107157SelW127, 168, 244Riboflavin194SOD3208TRXR1137Ascorbate218, 257O2-XanthineCalcium239Kynureninase176Methionine190ADPTrx-(SH)267, 137NitrotyrosineONOO-/ONOOHNitrotyrosine5050ATPLeukotriene E4Leukotriene E4129FructosamineLeukotriene F4GlucoseFructosamine82, 129106, 157264264Iron239HypoxanthineTRXR3FLAD1123, 214Ascorbic acid83, 218, 266