Entrez Gene 23236 Entrez Gene 9021 Entrez Gene 5290 Entrez Gene 6198 KRAS Entrez Gene 8027 RAF1 Entrez Gene 10254 Entrez Gene 5293 Entrez Gene 5294 Homo sapiens FYN Entrez Gene 2534 NetPath 14 - IL-2 Signaling Pathway NetPath (http://www.netpath.org) is a collaborative project between PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and the Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the NetPath website until the pathway is published. (GenMAPP notes) Cellular Process (WikiPathways-category) Interleukin-2 belongs to a family of cytokines, which includes IL-4, IL-7, IL-9, IL-15 and IL-21. IL-2 signals through a receptor complex consisting of IL-2 specific IL-2 receptor alpha (CD25), IL-2 receptor beta (CD122) and a common gamma chain (γc), which is shared by all members of this family of cytokines. Binding of IL-2 activates the Ras/MAPK, JAK/Stat and PI 3-kinase/Akt signaling modules. Source: NetPath http://www.netpath.org/pathways?path_id=NetPath_14 (WikiPathways-description) http://www.netpath.org (GenMAPP remarks) IL-2 Signaling Pathway Entrez Gene 207 PRKCZ Entrez Gene 3560 Entrez Gene 3561 Entrez Gene 3559 Entrez Gene 5291 CRKL IRS2 Entrez Gene 5594 Entrez Gene 5777 Entrez Gene 5296 Entrez Gene 5295 CBL PIK3CG Entrez Gene 3932 Entrez Gene 3717 ITM2B Entrez Gene 3667 Entrez Gene 8660 Entrez Gene 9846 Entrez Gene 6850 NR3C1 Entrez Gene 596 Entrez Gene 9445 Entrez Gene 5590 Entrez Gene 2908 Entrez Gene 2114 IL2 Entrez Gene 5595 PLCB1 IL2 PTPN6 MAPK1 RELA ICAM1 IL2RG STAM2 SOS1 TERT CD53 MAPK3 RELA Entrez Gene 3558 FRAP1 Entrez Gene 3716 ETS1 Entrez Gene 3718 MAPK14 PIK3CA IRS1 IL2 MAPK3 NFKB1 GAB2 MAPK9 AKT1 GRB2 IL2 SHC1 MAPK1 MAPKAPK2 MAPK8 CISH MAP2K2 SYK Entrez Gene 6774 IFNA1 Entrez Gene 8662 CREB1 STAT1 Entrez Gene 6772 STAT3 PIK3CB SOCS1 AKT1 SOCS3 BCL2 STAT5B CHUK TERT MAP2K1 IL2RA HSPCA AKT1 CRK RAF1 FOXO3A PTK2B ETS2 LYN JAK2 NFKB1 GNB2L1 PTPN11 VAV1 EIF3S9 NMI JAK1 STAT5B Entrez Gene 2475 Entrez Gene 3439 NSEP1 Entrez Gene 8569 Entrez Gene 3320 CRK Entrez Gene 1977 STAM Entrez Gene 6654 Entrez Gene 8651 Entrez Gene 1154 Entrez Gene 10399 Entrez Gene 1399 JAK3 PIK3R1 Entrez Gene 1385 Entrez Gene 5604 SHB Entrez Gene 5605 Entrez Gene 7409 Entrez Gene 6776 PIK3R2 Entrez Gene 867 Entrez Gene 1398 RPS6KB1 NSEP1 Entrez Gene 6461 Entrez Gene 2113 LCK Entrez Gene 9111 Entrez Gene 5970 PIK3CD Entrez Gene 4790 Entrez Gene 6777 Entrez Gene 3845 Entrez Gene 4904 STAT5A Entrez Gene 2309 MKNK1 Entrez Gene 7015 STAT5A IL2RB Entrez Gene 6464 Entrez Gene 4067 EIF4E Entrez Gene 5781 Entrez Gene 1432 Entrez Gene 9261 Entrez Gene 5599 Entrez Gene 5601 Entrez Gene 1147 Entrez Gene 2885 Entrez Gene 5894 IL2 Entrez Gene 3383 Entrez Gene 963 Entrez Gene 2185