Ensembl ENSG00000101460 Ensembl ENSG00000097033 Ensembl ENSG00000101844 Ensembl ENSG00000144848 ATG10 IR ULK2 Ensembl ENSG00000198382 Ensembl ENSG00000145782 ATG4 Ensembl ENSG00000057663 Homo sapiens Cellular Process (WikiPathways-category) Programmed cell death: autophagic cell death. Autophagy (self-eating) is a survival mechanism deployed by cells to cope with conditions of nutrient deprivation. However, unrestrained autophagy can result in genetically programmed cell death. Carbon nanotubes, PAMAMs, and iron oxide nanoparticles were reported to trigger autophagic cell death through the perturbation of the mTOR pathway, while gold nanoparticles may induce autophagy blockade through lysosomal impairment. (WikiPathways-description) Nanoparticle triggered autophagic cell death Ensembl ENSG00000085978 ATG12 NanoParticle Ontology NPO_401 Uniprot P01308 Ensembl ENSG00000171105 Ensembl ENSG00000165699 Ensembl ENSG00000197548 p150 VMP1 PI3KCIII Gold nanoparticles induce autophagosome accumulation through size-dependent nanoparticle uptake and lysosome impairment. PubMed 2011 21974862 ACS Nano Yu L Jin S Liang XJ Ma X Wu Y Tian Y Zhao Y Zhang X Au NP ATG3 ATG16L Ensembl ENSG00000177169 Ensembl ENSG00000152348 Ensembl ENSG00000062716 Atg14L LC3-II Ensembl ENSG00000181652 Ensembl ENSG00000110497 Ensembl ENSG00000126775 Ensembl ENSG00000167670 Ensembl ENSG00000103197 Ensembl ENSG00000126581 PI3KCIII Carbon nanotube 3-MA NanoParticle Ontology NPO_606 TCS-1 ATG7 Bif1 UVRAG ATG9 Ambra1 LC3-I AMPK TCS-2 Beclin1 BCL-2 Ensembl ENSG00000171791 PubChem-compound 1673 PI3k/AKT Insulin Beclin1 p150 Induction of ROS, mitochondrial damage and autophagy in lung epithelial cancer cells by iron oxide nanoparticles. PubMed 2012 22098780 Biomaterials Chauhan LK Patil G Ahmad I Mohammad A Naqvi SA Khan MI ATG5 Ensembl ENSG00000083290 NanoParticle Ontology NPO_965 A functionalized single-walled carbon nanotube-induced autophagic cell death in human lung cells through Akt-TSC2-mTOR signaling. PubMed 2011 21593791 Cell Death Dis Yang P Zhang YX Guo F Wang YG Zhang GG Jiang CY Sun Y Li CG Yang N Zhang YL Zhao Y Liu HL Liu XQ ULK1 NanoParticle Ontology NPO_273 PAMAM PI3KCIII PAMAM nanoparticles promote acute lung injury by inducing autophagic cell death through the Akt-TSC2-mTOR signaling pathway. PubMed 2009 19516051 J Mol Cell Biol Wang H Liu H Rao S Jiang C Xu H Guo F Guo C Miao Y Deng J Li B Chen X Sun Y Meng J Li L Li C Li D Zhang Y FeO NP