Ensembl
ENSG00000101460
Ensembl
ENSG00000097033
Ensembl
ENSG00000101844
Ensembl
ENSG00000144848
ATG10
IR
ULK2
Ensembl
ENSG00000198382
Ensembl
ENSG00000145782
ATG4
Ensembl
ENSG00000057663
Homo sapiens
Cellular Process (WikiPathways-category)
Programmed cell death: autophagic cell death. Autophagy (self-eating) is a survival mechanism deployed by cells to cope with conditions of nutrient deprivation. However, unrestrained autophagy can result in genetically programmed cell death. Carbon nanotubes, PAMAMs, and iron oxide nanoparticles were reported to trigger autophagic cell death through the perturbation of the mTOR pathway, while gold nanoparticles may induce autophagy blockade through lysosomal impairment. (WikiPathways-description)
Nanoparticle triggered autophagic cell death
Ensembl
ENSG00000085978
ATG12
NanoParticle Ontology
NPO_401
Uniprot
P01308
Ensembl
ENSG00000171105
Ensembl
ENSG00000165699
Ensembl
ENSG00000197548
p150
VMP1
PI3KCIII
Gold nanoparticles induce autophagosome accumulation through size-dependent nanoparticle uptake and lysosome impairment.
PubMed
2011
21974862
ACS Nano
Yu L
Jin S
Liang XJ
Ma X
Wu Y
Tian Y
Zhao Y
Zhang X
Au NP
ATG3
ATG16L
Ensembl
ENSG00000177169
Ensembl
ENSG00000152348
Ensembl
ENSG00000062716
Atg14L
LC3-II
Ensembl
ENSG00000181652
Ensembl
ENSG00000110497
Ensembl
ENSG00000126775
Ensembl
ENSG00000167670
Ensembl
ENSG00000103197
Ensembl
ENSG00000126581
PI3KCIII
Carbon nanotube
3-MA
NanoParticle Ontology
NPO_606
TCS-1
ATG7
Bif1
UVRAG
ATG9
Ambra1
LC3-I
AMPK
TCS-2
Beclin1
BCL-2
Ensembl
ENSG00000171791
PubChem-compound
1673
PI3k/AKT
Insulin
Beclin1
p150
Induction of ROS, mitochondrial damage and autophagy in lung epithelial cancer cells by iron oxide nanoparticles.
PubMed
2012
22098780
Biomaterials
Chauhan LK
Patil G
Ahmad I
Mohammad A
Naqvi SA
Khan MI
ATG5
Ensembl
ENSG00000083290
NanoParticle Ontology
NPO_965
A functionalized single-walled carbon nanotube-induced autophagic cell death in human lung cells through Akt-TSC2-mTOR signaling.
PubMed
2011
21593791
Cell Death Dis
Yang P
Zhang YX
Guo F
Wang YG
Zhang GG
Jiang CY
Sun Y
Li CG
Yang N
Zhang YL
Zhao Y
Liu HL
Liu XQ
ULK1
NanoParticle Ontology
NPO_273
PAMAM
PI3KCIII
PAMAM nanoparticles promote acute lung injury by inducing autophagic cell death through the Akt-TSC2-mTOR signaling pathway.
PubMed
2009
19516051
J Mol Cell Biol
Wang H
Liu H
Rao S
Jiang C
Xu H
Guo F
Guo C
Miao Y
Deng J
Li B
Chen X
Sun Y
Meng J
Li L
Li C
Li D
Zhang Y
FeO NP