MAP3K7 Homo sapiens B Cell Receptor Signaling Pathway NetPath 12 - B Cell Receptor Signaling pathway. NetPath (http://www.netpath.org) is a collaborative project between PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and the Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the NetPath website until the pathway is published. (GenMAPP notes) Cellular Process (WikiPathways-category) The B cell receptor includes membrane μ heavy chain molecules bound to a light chain and an Ig alpha (CD79A)/Ig beta (CD79B) heterodimer. Activation of the B cell receptor involves phosphorylation of the cytoplasmic immunoreceptor tyrosine-based activation motifs (ITAMs) present in Ig alpha and beta. This leads to activation of several non-receptor tyrosine kinases including those of the Src, Tec and Syk family of kinases. Downstream messengers include DAG, IP3, MAPK/ERK and JNK signaling modules. Source: NetPath http://www.netpath.org/pathways?path_id=NetPath_12 (WikiPathways-description) http://www.netpath.org (GenMAPP remarks) Entrez Gene 640 Entrez Gene 974 Entrez Gene 2534 PLEKHA1 CBL Gene Symbol BRDG1 AKT1 PIP5K2B PTPN6 HNRPK ATP2B4 PLEKHA2 Entrez Gene 1147 Entrez Gene 2932 Entrez Gene 3551 Entrez Gene 1021 CSK Entrez Gene 1499 CRK PTPN6 GSK3B BLK BAX BANK1 RHOA BAX MAP2K2 CHUK CCNE1 BLNK SHC1 RAPGEF1 CDK2 LCK BCL2L11 LYN PTK2 PTPN18 PIP5K1C NFATC3 NFKBIA CRK VAV2 CD72 SYK BRAF PPP3CB RELA LIME1 MAPK3 SH3BP2 GTF2I PLCG2 PILRB GRB2 JUN MAPK4 BCL2 RPS6 LYN NFATC1 CD5 LAT2 IKBKB PDPK1 PIP5K1B DOK1 PRKD1 PIP5K2A GAB1 ITK HCLS1 WAS PIK3AP1 PRKCD RPS6KB1 RAPGEF1 LAT2 PIP5K2B CTNNB1 PDK2 CDK6 CASP9 ITPR2 HDAC7A STAT1 CDK7 ARPC4 NFATC2 PTPRC Entrez Gene 6654 Entrez Gene 2885 SHC1 Entrez Gene 7409 Entrez Gene 4690 Entrez Gene 10092 CD79B IGHM Entrez Gene 10093 HCLS1 Entrez Gene 1380 Entrez Gene 930 Entrez Gene 975 Entrez Gene 5336 CYCS Entrez Gene 5335 CHUK Entrez Gene 7454 Entrez Gene 3059 Entrez Gene 5777 Entrez Gene 5747 PIK3R1 CCNA2 Entrez Gene 921 Entrez Gene 11184 Entrez Gene 10109 Entrez Gene 10094 DUSP4 HDAC5 TEC Entrez Gene 10096 ARPC3 Entrez Gene 10095 Entrez Gene 581 Entrez Gene 5164 Entrez Gene 673 Entrez Gene 25780 Entrez Gene 5587 Entrez Gene 7410 Entrez Gene 6452 GTF2I Entrez Gene 868 Entrez Gene 840 NFATC2 Entrez Gene 10097 Entrez Gene 3708 Entrez Gene 493 Entrez Gene 387 PLEKHA2 CARD11 Entrez Gene 5294 RAP2A CTNNB1 INPP5D REL Entrez Gene 5530 SYK Entrez Gene 5532 MAP4K1 Entrez Gene 4773 Entrez Gene 4775 Entrez Gene 5581 BLNK FCGR2B Entrez Gene 2549 PTK2B ARP3 RASGRP3 HDAC7A Entrez Gene 2969 Entrez Gene 10603 PRKCQ PIP5K1A RPS6KA1 Entrez Gene 4067 VAV1 MAPK14 Entrez Gene 27071 Entrez Gene 6850 CD19 RASA1 Entrez Gene 59339 Entrez Gene 29760 Entrez Gene 59338 PLCG2 Entrez Gene 6655 PIP5K2B AKT1 PLEKHA1 SOS2 NCK1 DAPP1 CD79A CCND3 ARPC2 CD81 PPP3CA Entrez Gene 4792 APS GSK3A ARPC5 Entrez Gene 5966 Entrez Gene 5970 INPP5D GAB2 Entrez Gene 971 Entrez Gene 5579 PIP5K1B BCL10 RELA ZAP70 Entrez Gene 2308 IKBKB Entrez Gene 207 Entrez Gene 5170 ATF2 SLA2 Entrez Gene 5911 NEDD9 Entrez Gene 2931 PRKCE Entrez Gene 5588 CBLB BTK Entrez Gene 4772 MAPK8 Entrez Gene 5534 PIP5K1B Entrez Gene 5788 Entrez Gene 3190 Entrez Gene 6198 CD22 HCLS1 CYCS Entrez Gene 3635 Entrez Gene 79930 PIK3AP1 Entrez Gene 5599 DUSP6 Entrez Gene 2213 MAP2K1 Entrez Gene 54205 BRAG Entrez Gene 10014 Entrez Gene 51564 CR2 RASGRP3 Entrez Gene 1022 Entrez Gene 973 SYK REL PPP3R1 Entrez Gene 1432 FOXO1A Entrez Gene 1386 SOS1 Entrez Gene 3725 PRKCB1 Entrez Gene 9846 Entrez Gene 6194 Entrez Gene 8915 Entrez Gene 84433 BTK Entrez Gene 6885 PTPN11 MAPK1 Entrez Gene 1445 Entrez Gene 54923 PIK3R2 Entrez Gene 5925 Entrez Gene 1019 BCL6 Entrez Gene 9261 Entrez Gene 1017 PRKCD Entrez Gene 898 Entrez Gene 890 Entrez Gene 604 DOK3 CMTM3 RPS6KA1 IKBKG Entrez Gene 8517 PIP5K2C Entrez Gene 894 Entrez Gene 896 ITPR1 CDK4 PIK3CG CARD11 Entrez Gene 7006 Entrez Gene 3702 Entrez Gene 2889 Entrez Gene 84174 Entrez Gene 1398 HCK Entrez Gene 3937 Entrez Gene 3507 FYN NFATC3 Entrez Gene 596 Entrez Gene 4739 Entrez Gene 123920 Entrez Gene 2185 Entrez Gene 51363 HDAC5 Entrez Gene 3055 Entrez Gene 1399 LCP2 Entrez Gene 55024 RAF1 CCND2 Entrez Gene 26228 RB1 Entrez Gene 1796 GRB2 Entrez Gene 26469 Entrez Gene 8394 Entrez Gene 5305 Entrez Gene 3709 PTPN6 Entrez Gene 5781 PRKCE Entrez Gene 29990 Entrez Gene 842 Entrez Gene 933 ARPC1B DAPP1 PLCG1 Entrez Gene 23396 Entrez Gene 8396 Entrez Gene 8395 BCAR1 Entrez Gene 6195 MAPKAPK2 Entrez Gene 79837 CRKL Entrez Gene 5604 Entrez Gene 5295 Entrez Gene 5894 Entrez Gene 5296 Entrez Gene 1846 Entrez Gene 5605 CASP7 GAB1 Entrez Gene 2002 Entrez Gene 1848 STAT3 ARP2 Entrez Gene 118788 Entrez Gene 5594 CREB1 Entrez Gene 5921 Entrez Gene 5580 Entrez Gene 5595 LYN Entrez Gene 1385 Entrez Gene 6774 Entrez Gene 7462 Entrez Gene 867 Entrez Gene 6772 Entrez Gene 695 Entrez Gene 7535 Entrez Gene 10018 PRKCB1 Entrez Gene 5596 ELK1 Entrez Gene 9564 Entrez Gene 3932 Entrez Gene 6464 CD79A