This pathway is modeled after Figure 5 of the article "Glomerulocystic kidney disease" (Bissler, et al. 2010). The gene product Wnt signals two different paths titled canonical and non-canonical. The non-canonical path is mediated by the membrane bound protein Disheveled (Dvl) which then controls the planar cell Polarity. The canonical path on the other hand is mediated by the cytoplasmic protein Disheveled (Dvl) and then is effected through b-catenin transcription. The complex of Nphp2 and Nphp3 seem to help facilitate the process by controlling the Wnt signaling. Bergmann, et al. (2008) showed that Nphp3 deficiency in Xenopus resulted to planar cell polarity defects.This pathway was inferred from Mus musculus pathway "Wnt Signaling in Kidney Disease", WP3857 revision 90183, with a 97.0% conversion rate.b22b30Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000032558No homologues found for original id En:ENSMUSG00000007815Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000006932Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000028344Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000024913Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000030201Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22408Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22409Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22410Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22421Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:93735Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22420Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22418Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22414Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22411Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22417Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22416Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22419Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22412Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22413Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22415Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22422Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14362Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14370Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14366Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:57265Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14369Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14371Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14367Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14368Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14365Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14362Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14370Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14366Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:57265Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14369Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14371Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14367Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14368Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14365Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13543Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13544Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13542Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26420Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26414Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26419Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13543Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13544Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13542Proposed Inhibition signaling pathwayPW:0000003Pathway Ontology18371931PubMedLoss of nephrocystin-3 function can cause embryonic lethality, Meckel-Gruber-like syndrome, situs inversus, and renal-hepatic-pancreatic dysplasia.Am J Hum Genet2008Bergmann CFliegauf MBrüchle NOFrank VOlbrich HKirschner JSchermer BSchmedding IKispert AKränzlin BNürnberg GBecker CGrimm TGirschick GLynch SAKelehan PSenderek JNeuhaus TJStallmach TZentgraf HNürnberg PGretz NLo CLienkamp SSchäfer TWalz GBenzing TZerres KOmran H20091054PubMedGlomerulocystic kidney disease.Pediatr Nephrol2010Bissler JJSiroky BJYin Hkidney diseaseDOID:557DiseaseWnt signaling pathwayPW:0000008Pathway OntologyWnt signaling, the planar cell polarity pathwayPW:0000200Pathway OntologyRap1 mediated signaling pathwayPW:0000386Pathway OntologyWnt signaling pathwayPW:0000008Pathway OntologyWnt signaling, the planar cell polarity pathwayPW:0000200Pathway Ontologykidney diseaseDOID:557Disease