Model of eIF5A regulation in response to inhibition of the nuclear export system. Under normal conditions, IGF2BP1 is exported by XPO1 and binds to eIF5A in cytoplasm. The binding with IGF2BP1 prevents eIF5A from accumulating in mitochondria. SINE (Selective Inhibitors of Nuclear Export) inhibits the nuclear export of IGF2BP1, resulting in decreased cytoplasmic IGF2BP1. Unbound eIF5A accumulates in mitochondria and induces apoptosis.b5725878333PubMedXPO1/CRM1 Inhibition Causes Antitumor Effects by Mitochondrial Accumulation of eIF5A.Clin Cancer Res2015Miyake TPradeep SWu SYRupaimoole RZand BWen YGharpure KMNagaraja ASHu WCho MSDalton HJPrevis RATaylor MLHisamatsu TKang YLiu TShacham SMcCauley DHawke DHWiktorowicz JEColeman RLSood AKnuclear protein transport pathwayPW:0000538Pathway Ontology