Rückert F et al. Examination of Apoptosis Signaling in Pancreatic Cancer by Computational Signal Transduction Analysis.
PLoS ONE, 2010. 5: e12243Arrows: activation, broken arrows: inhibtionApoptosis, or cell death program, can be activated by various mechanisms within the extrinsic and the intrinsic pathway. While activation of cell death receptors leads to the engagement of the extrinsic pathway, the intrinsic pathway is activated by mitochondria during cellular stress, both
resulting in an activation of caspases.
In the present pathway we emphasized the activation of caspases by those two pathways in pancreatic cancer (PDAC) cells. Please notice, that PDAC cells are so called type-II cells. In these cells the activation of cell death receptors is not sufficient to activated caspases. By cleavage of Bid, type-II cells activate the intrinsic pathway as "amplification loop".
Cellular ProcessPhysiological Processbc6cda17404574PubMedmir-29 regulates Mcl-1 protein expression and apoptosis.Oncogene2007Mott JLKobayashi SBronk SFGores GJapoptotic cell death pathwayPW:0000009Pathway Ontology20808857PubMedExamination of apoptosis signaling in pancreatic cancer by computational signal transduction analysis.PLoS One2010Rückert FDawelbait GWinter CHartmann ADenz AAmmerpohl OSchroeder MSchackert HKSipos BKlöppel GKalthoff HSaeger HDPilarsky CGrأ¼tzmann Rsignaling pathwayPW:0000003Pathway Ontologyregulatory pathwayPW:0000004Pathway Ontology