The folic acid-centred micronutrient biological network. The most relevant biochemical processes related to folic acid in the context of metabolism, oxidation and inflammation are represented. Also, the compartmental separation (intracellular vs. plasma) is presented, identifying the folic acid centred plasma metabolome.
Metabolic Process
Monocyte Chemotactic Protein 1
CCL2
efb
f21
f03
d18
f21
solute carrier family 19 (folate transporter), member 1
ef8
f21
Prostaglandin F2a
f03
add
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2
folate receptor 2 (fetal)
e2f
nuclear factor NF-kappa-B p50 subunit
bc2
Prostaglandin E1
e06
folate receptor 3 (gamma)
e2f
nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65
bc2
Monocyte Chemotactic Protein 1
CCL2
efb
Prostaglandin F2a
f03
add
solute carrier family 46 (folate transporter), member 1
ef8
folate receptor 4 (delta) homolog (mouse)
e2f
folate receptor 1 (adult)
e2f
Prostaglandin E2
f03
eb6
Prostaglandin E1
e06
afd
Prostaglandin E2
f03
eb6
tumor protein p53
e4d
f1c
e26
fc9
f7c
fa0
bc2
bc2
EC 3.5.4.9
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
af8
EC 1.16.1.8
5-methyltetrahydrofolate-homocysteine methyltransferase reductase
c3a
a7c
EC 3.3.1.1
Adenosylhomocysteinase
e10
EC 2.1.2.1
Serine hydroxymethyltransferase
c29
af8
EC 1.5.1.3
Dihydrofolate reductase
a2c
ad8
ef2
EC 2.5.1.6
Methionine adenosyltransferase
e4d
EC 1.5.1.5
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1
af8
aa9
EC 2.1.1.13
5-methyltetrahydrofolate-homocysteine methyltransferase
Also known as MS
fe7
c2d
b2a
a7c
EC 4.2.1.22
cystathionine-beta-synthase
cb6
fe7
Nicotinamide adenine dinucleotide phosphate-Oxidized
Nicotinamide adenine dinucleotide phosphate-Oxidized
Nicotinamide adenine dinucleotide phosphate-Oxidized
Nicotinamide adenine dinucleotide phosphate-Oxidized
Nicotinamide adenine dinucleotide phosphate-Oxidized
Nicotinamide adenine dinucleotide phosphate-Oxidized
Nicotinamide adenine dinucleotide phosphate-Oxidized
EC 1.11.1.7
Myeloperoxidase
c2b
aac
c51
ceb
EC 1.11.1.7
Myeloperoxidase
c2b
aac
c51
ceb
EC 1.11.1.6
fec
de0
Nitric oxide synthase
afd
EC 3.4.21.21
coagulation factor VII (serum prothrombin conversion accelerator)
cc7
c0b
EC 3.4.21.68
plasminogen activator, tissue
f7a
EC 3.4.21.7
Plasminogen
f7a
Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
f7a
EC 3.4.21.5
coagulation factor II (thrombin)
f17
cc7
EC 3.4.21.68
plasminogen activator, tissue
f7a
EC 3.4.21.21
coagulation factor VII (serum prothrombin conversion accelerator)
cc7
c0b
EC 3.4.21.5
coagulation factor II (thrombin)
f17
cc7
EC 3.4.21.7
Plasminogen
f7a
Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
f7a
EC 1.11.1.12
Selenoprotein-glutathione peroxidase 4
Hydrogen peroxide
10-formyltetrahydrofolate
af8
5,10-Methenyltetrahydrofolic acid
af8
5-Formyltetrahydrofolate
af8
formylglycinamide ribonucleotide
af8
e70
(11R)-hydroxymethylenetetrahydrofolate
af8
(11S)-hydroxymethylenetetrahydrofolate
af8
a2c
glycinamide ribonucleotide
af8
e70
5,10-Methylenetetrahydrofolate
a2c
af8
5-methyltetrahydrofolate
Predominant food folate
a2c
b2a
Generic term used to denote both naturally occurring folate in foods (food folate) and the synthetic form of the vitamin (folic acid).
a2c
e4d
e2f
ef8
bc1
be5
ac7
fa3
c76
efb
d08
5-methyltetrahydrofolate
Predominant food folate
Generic term used to denote both naturally occurring folate in foods (food folate) and the synthetic form of the vitamin (folic acid).
a2c
EC 1.15.1.1
superoxide dismutase 3, extracellular
EC 1.15.1.1
superoxide dismutase 3, extracellular
EC 2.7.1.26
riboflavin kinase
a22
Glutathione disulfide
EC 1.11.1.9
Selenoprotein-glutathione peroxidase 3
EC 1.11.1.9
Selenoprotein-glutathione peroxidase 3
EC 4.4.1.1
cystathionase
fe7
de0
fec
cb6
Tetrahydrofolic acid
a2c
Nicotinamide adenine dinucleotide phosphate-Reduced
Nicotinamide adenine dinucleotide phosphate-Reduced
Nicotinamide adenine dinucleotide phosphate-Reduced
Nicotinamide adenine dinucleotide phosphate-Reduced
Nicotinamide adenine dinucleotide phosphate-Reduced
Nicotinamide adenine dinucleotide phosphate-Reduced
Nicotinamide adenine dinucleotide phosphate-Reduced
EC 1.11.1.9
Selenoprotein-glutathione peroxidase 6
Synthetic folate
c2d
a2c
f5b
Synthetic folate
c2d
a2c
f5b
EC 1.11.1.9
Selenoprotein-glutathione peroxidase 2
EC 1.11.1.9
Selenoprotein-glutathione peroxidase 1
reactive nitrogen species
http://en.wikipedia.org/wiki/Reactive_nitrogen_species
fec
f11
EC 1.5.1.20
5,10-methylenetetrahydrofolate reductase
Homozygous of (MTHFR) 677C-T variant may have enzyme activities up to 50% lower than those without the polymorphism increasing the risk of hyperhomocysteinemia
c2d
a2c
EC 2.1.2.2
phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
af8
e70
EC 6.3.3.2
5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)
af8
EC 2.1.2.1
Serine hydroxymethyltransferase 1 (soluble)
af8
c0b
b2a
ae8
d77
c22
ba1
fc5
fa3
efb
c0b
EC 1.15.1.1
superoxide dismutase 1, soluble
Vitamin B6
bf9
cda
afd
bf9
cda
ac7
fa3
af8
c29
af8
c29
af8
c29
serum amyloid A4, constitutive
e99
ea2
high-density lipoprotein
SAA circulates in plasma as a constituent of high density lipoproteins (HDL).
e99
ea2
c7d
high-density lipoprotein
e99
c76
serum amyloid A1
e99
ea2
very-low-density lipoprotein
The VLDL is produced in the liver, contains one molecule of apoB100
de8
apolipoprotein A-I
e99
very-low-density lipoprotein
de8
ba4
serum amyloid A3 pseudogene
e99
ea2
Flavin Mononucleotide
af3
high-density lipoprotein cholesterol
Cholesterol transport
e99
low-density lipoprotein
b63
aac
caf
ae8
c76
Nitrotyrosinated apolipoprotein A-I
c65
serum amyloid A2
e99
ea2
scavenger receptor class B, member 1
c7d
low density lipoprotein receptor
e9b
oxidized low-density lipoprotein
b63
aac
caf
ae8
alpha-1-antichymotrypsin
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
e9b
ce6
e99
Triglyceride
Triacylglycerol
de8
very-low-density lipoprotein-triglyceride
Triglyceride transport
de8
ATP-binding cassette, sub-family A (ABC1), member 1
e99
c7d
high-density lipoprotein
ApoA-I is present on the majority of HDL particles and constitutes aprox 70% of the apolipoprotein content of HDL particles
e99
apolipoprotein B
de8
very-low-density lipoprotein-triglyceride
Triglyceride transport
de8
Triglyceride
Triacylglycerol
de8
very-low-density lipoprotein
de8
ba4
apolipoprotein B
de8
oxidized low-density lipoprotein
b63
aac
caf
ae8
low-density lipoprotein
b63
aac
caf
ae8
c76
alpha-1-antichymotrypsin
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
e9b
ce6
high-density lipoprotein
e99
c76
e99
high-density lipoprotein cholesterol
Cholesterol transport
e99
apolipoprotein A-I
e99
d63
Flavin adenine dinucleotide
af3
8-Hydroxy-deoxyguanosine
be4
Reduced cobalamin
a7c
c3a
cfb
Flavin adenine dinucleotide
a7c
oxidized cobalamin
a7c
c3a
Reduced cobalamin
a7c
c3a
cfb
8-Hydroxy-deoxyguanosine
be4
Adenosine diphosphate
Adenosine diphosphate
fc5
fa3
EC 1.15.1.1
superoxide dismutase 2, mitochondrial
af8
c29
Adenosine triphosphate
Nitrogen dioxide
ozone
Nitrous acid
Nitric oxide
ceb
c51
f1c
fc5
fa3
Nitric oxide
ceb
c51
Hypochlorite
af4
d08
colony stimulating factor 1 (macrophage)
e2f
interferon, gamma
bd7
interleukin 6 (interferon, beta 2)
fc9
d53
d77
af4
interleukin 2
f7c
a54
C-reactive protein, pentraxin-related
ed1
a40
caf
e34
be5
afd
interferon, gamma
b42
e34
Insulin
b4a
b59
ba4
interferon, gamma
bd7
interleukin 1, beta
b78
Glycated hemoglobin
http://en.wikipedia.org/wiki/Glycated_hemoglobin
cef
albumin
c31
albumin
c31
Insulin receptor
b4a
e66
hemoglobin, beta
cef
colony stimulating factor 1 (macrophage)
e2f
Glycated hemoglobin
http://en.wikipedia.org/wiki/Glycated_hemoglobin
cef
soluble intercellular adhesion molecule 1
e34
cd0
c22
interleukin 6 (interferon, beta 2)
fc9
d53
interleukin 4
f7c
hemoglobin, alpha 1
cef
interleukin 2
f7c
a54
tumor necrosis factor (TNF superfamily, member 2)
dde
d77
e34
b4a
Insulin
b4a
b59
ba4
fa3
interleukin 1, beta
b78
d77
interferon, gamma
b42
f17
f7a
http://en.wikipedia.org/wiki/Fibrin_degradation_product
f7a
a00
tumor necrosis factor (TNF superfamily, member 2)
dde
interleukin 4
f7c
http://en.wikipedia.org/wiki/Fibrin_degradation_product
f7a
a00
f17
f7a
af4
d08
ca9
Superoxide
aa7
a2c
b2a
a2c
a7c
b54
a2c
d82
aa7
a2c
d82
a2c
a7c
b54
e4d
Adenosine diphosphate
f11
H4B
fa3
ac7
Peroxynitrite
f11
Adenosine triphosphate
Adenosine triphosphate
c31
b59
cef
b59
cef
c31
f5f
f5f
EC 2.7.7.2
FAD1 flavin adenine dinucleotide synthetase homolog (S. cerevisiae)
a22
b21
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aff
fec
c2b
e26
d77
fec
b53
b63
e99
f11
d63
a40
b59
af8
e70
be4
f1c
bc1
ba1
e4d
ad3
f4a
fa3
fa0
a54
d53
b78
dde
b42
bd7
d77
c22
ae2
d08
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